This study was based on evaluating anti-inflammatory activities of ethanolic extracts from Stevia leaves (EESL) and Fenugreek seeds (EEFS) (in vitro and in vivo). In the in vitro experiment, the results exhibited potent anti-inflammatory activity. The combination of both extracts (1:1, 100 g) showed to be the most potent inhibitor of COX-2 with inhibition % (83.64%). This result was comparable with the standard Celecoxib showed higher level of inhibition, (86.63%, 100 g). While, EESL showed the highest activity as COX-1 inhibitory activity (74.35%, 100 g), which it is higher than standard Celecoxib (67.64%, 100 g). In vivo anti-inflammatory activity was performed on Wistar rats at the doses 200 and 400 mg/kg body weight using the carrageenan-induced rat paw edema modal. Combination of (SLEE + FSEE, each 100 mg) displayed the highest significant anti-inflammatory activity (0.46ef± 0.025, p < 0.05) after 4 h, compared with indomethacin (0.44f ± 0.025, p < 0.05). The results indicated that these plants may have a role for discovering new anti-inflammatory natural drugs. Furthermore, Stevia leaves and Fenugreek seeds can be subjected to further investigations as anticancer agents.
El-Taib, M., Fakhry, G., Khalifa, Y., & Haredy, H. (2020). Anti-inflammatory activity in vitro and in vivo of ethanolic extracts of Stevia rebaudiana Bertoni and Trigonella foenum-graecum. Scientific Journal of Agricultural Sciences, 2(2), 137-143. doi: 10.21608/sjas.2020.48817.1053
MLA
Medhat I. El-Taib; Gamal Fakhry; Yasser Khalifa; Haredy Haredy. "Anti-inflammatory activity in vitro and in vivo of ethanolic extracts of Stevia rebaudiana Bertoni and Trigonella foenum-graecum". Scientific Journal of Agricultural Sciences, 2, 2, 2020, 137-143. doi: 10.21608/sjas.2020.48817.1053
HARVARD
El-Taib, M., Fakhry, G., Khalifa, Y., Haredy, H. (2020). 'Anti-inflammatory activity in vitro and in vivo of ethanolic extracts of Stevia rebaudiana Bertoni and Trigonella foenum-graecum', Scientific Journal of Agricultural Sciences, 2(2), pp. 137-143. doi: 10.21608/sjas.2020.48817.1053
VANCOUVER
El-Taib, M., Fakhry, G., Khalifa, Y., Haredy, H. Anti-inflammatory activity in vitro and in vivo of ethanolic extracts of Stevia rebaudiana Bertoni and Trigonella foenum-graecum. Scientific Journal of Agricultural Sciences, 2020; 2(2): 137-143. doi: 10.21608/sjas.2020.48817.1053