Determination of Physiochemical Properties, Amino Acids, and Other Bioactive Compounds of Silybum Marianum Seeds (Silybum Marianum L.).

Document Type : Original Article

Authors

1 Facility of agriculture Bnha university

2 Biochemistry Dept., Fac. Agric., Benha University, Egypt

Abstract

Silymarin extracted from Silybum marianum seeds is considered the main active component in Silybum marianum. Furthermore, multiple pre-clinical investigations have indicated that its major active component silybin has anti-tumoral action in several cancer cell lines, as it may cause growth inhibition and apoptosis and can improve the therapeutic potential of doxorubicin, cisplatin, and carboplatin. The majority of silybin's anticancer efficacy has been identified through in vitro research in tumor cells. In vitro and in vivo cells have revealed the efficacy of silymarin in the prevention 
and treatment of liver disorders and primary liver cancer. Remarkably high anti-tumor promoting activity and many other 
pharmacological activities have also been reported, Silymarin extract contains approximately 65% to 80% flavonolignans the chemical structures of silymarin indicated that silymarin is composed of a mixture of (8) major flavonolignans including (silychristins A and B, silydianin, silybins A and B and isosilybins A and B ¸ Also, 2,3-cis-silybin A and B have also been reported, Flavonoids represent 0.58% ¸ while, Phenols 1.15% and lipid 20.2%.

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Scientific Journal of Agricultural Sciences
Volume 6, Issue 1
March 2024
Pages 205-216

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